The name comes from Greek, meaning “between rivers”. The municipality settlements (beside Muzinë) are inhabited mainly by Greek minority.
The Mesopotam village is known for its 13th century Orthodox Church dedicated to St. Nicholas, declared “Protected Monument” from the government.
The “Blue Eye” (Albanian: Syri i Kaltër) water spring nearby is an well-known touristic destination. There is a local trout (Salmo obtusirostris) farm.